Bifidobacterium longum subsp. longum is a clinically effective, well-established, multifunctional probiotic that has a long history of human use in alleviating gastrointestinal, immunological and infectious diseases. Key clinical findings point out that could act as a microbiome modulator to orchestrate the physiological activities of gut communities. Specifically, modulates luminal metabolism, stabilizes gut microbiota, and ultimately drives a fine-tuned homeostatic balance within the host-microbiome interaction. Clinical evidence of effectiveness of and how such multifunctional activities take place would be
Bifidobacterium longum subsp. longum is one of the well-established probiotic strains with numerous profound health benefits in humans. It has been used as probiotic since its discovery for half a century and many studies have been conducted to clarify its effectiveness. Nonetheless, there is a lack of a detailed review about its beneficial properties that could provide both medical care professionals and the public more reliable health claims in helping them to make better-informed probiotics selection. In this review, we summarize the significant health benefits of it from the most relevant clinical and animal studies and try to provide a fundamental framework for a better understanding of the functional health effects of this. We believe that a comprehensive knowledge of human substantiation of efficacy as well as the potential mechanisms of action involved is essential for a more tailored and targeted application of probiotics. Here, we highlight that modulation of the gut microbiome is the principal beneficial action of it in humans.